Pulmonary Systems
Buxco offers a broad range of preclinical pulmonary research solutions. Well-known for our unrestrained whole body plethysmographs, Buxco is a leading supplier of other approaches to respiratory research. The systems below all interface with Buxco's FinePointe™ data acquisition and analysis software. Buxco also supplies an extensive selection of equipment for general purpose respiratory monitoring and research.
Buxco provides complete solutions – software and hardware – an assurance that all components have been designed to integrate properly and reliably.
Unrestrained Whole Body (Conscious, Unrestrained)
- Study conscious subjects in a low-stress environment
- High throughput and easy to operate
- Especially valuable for long term and repetitive studies
- Monitor breath frequency, tidal volume, peak flows, pauses, other flow derived parameters, and enhanced pause (an index of airway hyper-reactivity)
- Recommended for rodents through large species
These systems can be outfitted with temperature and humidity compensation, aerosol delivery, respiratory gas analysis, and urine collection. An optional tower chamber may be used for infusion, blood pressure monitoring, and EEG collection. Unrestrained Whole Body systems may also be used with telemetry for conscious resistance measurements and combined pulmonary-cardiovascular studies.
Restrained Whole Body (Conscious, Restrained)
Similar to the unrestrained system except subjects are kept in a small chamber to restrict movement. For rodents.
Double Chamber (Conscious, Restrained)
- Two chambers in one separated by an elastomeric seal
- Measure nasal flow in the head chamber and thoracic flow in the body chamber
- Subjects may be conscious or sedated
- Monitor flow derived parameters and specific airway resistance
- For rodents
These systems can be outfitted with aerosol delivery and can be used in combination with telemetry.
Head-out (Conscious, Restrained)
- Used extensively in safety pharmacology
- A quick, direct, and inexpensive solution for monitoring flow-derived parameters on conscious subjects
- Thoracic movement is monitored in a body chamber
- Subject's head extends through the chamber wall by way of an elastomeric seal
- This system requires no bias flow (may be used for body cooling for extended studies)
- For rodents
These systems can be used with telemetry for conscious resistance and combined pulmonary-cardiovascular measurements.
Nose-only (Conscious, Restrained)
Buxco produces nose-only plethysmographs to fit nose-only exposure towers. This system allows monitoring of flow derived parameters during exposures. An optional dosimetry software analyzer also computes exposure dosage. This system may also be used in combination with telemetry. For rodents.
Anesthetized Resistance and Compliance (Anesthetized)
- Directly measures flow and pressure on anesthetized subjects to calculate lung resistance and dynamic compliance
- Flow measurements may be collected using a plethysmograph (small subjects) or an in-line pneumotachograph
- Studies may be performed on ventilated or spontaneously-breathing subjects and systems may be outfitted with aerosol delivery
- Recommended for rodents through large species
FinePointe™ Resistance and Compliance (Anesthetized)
The FinePointe RC system is specially-designed version of the anesthetized resistance and compliance system described above. All electronics are combined in one small chassis, along with a respiration pump. Calibration is automated and operation has been simplified for ease-of-use and data consistency. Designed for rodents.
Forced Maneuvers (Anesthetized)
Buxco's forced maneuvers system is analogous to pulmonary function testing in cooperative humans. The system generates flow-volume and pressure-volume curves, along with a complete report of lung capacities, FEV(x), FEF(x), and other anatomical and physiological parameters. The forced maneuvers system also provides baseline measurement of lung resistance and dynamic compliance.
Laboratory components for general respiratory research
Buxco also offers general purpose components in support of a wide variety of research protocols: ventilators, dosing chambers, aerosol delivery systems, O2 and CO2 monitors, respiratory gas analyzers, pneumotachographs, and more.